NCCIH thanks Craig Hopp, Ph.D., and David Shurtleff, Ph.D., NCCIH, for reviewing the 2015 update of this fact sheet. Muscle twitches and cramps 9. The physicians who published his case in a medical journal are worried that others might fall into the same innocent trap. Elevated homocysteine levels are … The study is created by eHealthMe based on reports (from sources including the FDA) of 97,316 people who take Sam-e and Trazodone hydrochloride, and is updated regularly. (3), When doctors found that conditions like depression and liver disease were associated with abnormal levels of S-adenosylmethionine in the body, researchers began to investigate the efficacy of SAM-e in the treatment of these types of health concerns. (4). It appears that the compound has potential as a natural anti-inflammatory, pain-relieving and mood-boosting agent, but more human studies are needed to determine how exactly we should be using it. SAMe can chemically change levodopa in the body and decrease the effectiveness of levodopa. Researchers are still looking into whether or not S-adenosylmethionine is an effective dietary supplement for the treatment of osteoarthritis, or degenerative joint disease. More research is needed to know whether or not it’s safe to use SAM-e during pregnancy or when breastfeeding. Researchers also indicated that recent findings demonstrate SAM-e’s efficacy in patients that are non-responsive to selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors. Fatigue and weakness 5. This publication is not copyrighted and is in the public domain. In the U.S., it’s sold over-the-counter as a dietary supplement and can be found online or in health food stores. You are at greater risk for kidney disease if you have diabetes or high blood pressure. Improves Symptoms of Fibromyalgia. (9). Chronic kidney disease – a progressive type of kidney problem that gets worse over time – is the most common type of kidney disease. However, some of the studies used injected SAMe, which may not have the same effects as SAMe taken as a dietary supplement. SAMe has been investigated most extensively for depression, osteoarthritis, and liver diseases. Overall, more research is needed regarding the basic treatment of liver disease with SAM-e before concrete recommendations can be made. They concluded that S-adenosylmethionine “may be useful in improving spatial memory in patients suffering from many dementia forms including Alzheimer’s disease.” (13). High cholesterolBut even if you don’t have any risk factors, a yearly check-up with blood pressure check, lab and urine tests is the only way to get a clear picture of your kidney function, says Dr. Heyka.RELATED: Chro… (15). Although there are hints that it might be helpful for these conditions, the evidence is not conclusive. (2) What does this mean? Kidney Failure in Dogs and Cats: Where to Begin. Although it’s only available by prescription in Europe to treat conditions like depression and arthritis, the supplement is becoming more and more popular in the United States for a number of health concerns. Although more research is needed to determine the exact mechanisms and benefits of SAM-e, there is evidence that it may serve as a potential therapeutic agent for the following conditions. Nephritis and nephrosis can give rise to nephritic syndrome and nephrotic syndrome … S-Adenosyl-L-methionine (SAMe) for smoking abstinence: a randomized clinical trial. A few studies show that SAM-e is as effective as conventional treatments in treating osteoarthritis, but a panel could not recommend it for pain because of insufficient evidence. 6 Things You Should Know About Dietary Supplements for Osteoarthritis, Depression and Complementary Health Approaches, U.S. Department of Health & Human Services, 9000 Rockville Pike Bethesda, Maryland 20892, U.S. Department of Health and Human Services. Researchers concluded that SAM-e may have potential as a novel therapeutic agent for patients with chronic asthma symptoms, but more human studies will be needed to test SAM-e’s ability to reduce oxidative stress and positively impact airway inflammation. It’s also possible that SAMe might interact with drugs and dietary supplements that increase levels of serotonin (a chemical produced by nerve cells), such as antidepressants, L-tryptophan, and St. John’s wort. An animal model meta-analysis that was published in PLoS One evaluated the effect of SAM-e on cognitive ability as measured by maze performance in mice. Overall, the evidence that oral SAMe may be helpful for depression is not conclusive. Signs and symptoms of chronic kidney disease develop over time if kidney damage progresses slowly. Dr. Josh Axe is on a mission to provide you and your family with the highest quality nutrition tips and healthy recipes in the world...Sign up to get VIP access to his eBooks and valuable weekly health tips for FREE! Diabetes 2. are clickable links to these studies. Kidney disease means your kidneys are damaged and can’t filter blood the way they should. Some of the participants in the depression studies who also had osteoarthritis said their joint symptoms improved when they took SAMe. Basically, SAM-e is involved in many metabolic processes throughout the body, and it plays a role in the formation, activation and breakdown of many chemicals, including hormones and proteins. It is a naturally occurring, modified amino acid that is produced in virtually all cells and participates in many biochemical pathways as a major methyl donor and may play a role in intracellular interferon signaling. S-Adenosylmethionine for osteoarthritis of the knee or hip. S-Adenosyl-L-methionine (also called S-adenosyl methionine, S-adenosylmethionine, SAMe, or SAM-e in the United States or ademetionine in Europe, and also often abbreviated as SAM and AdoMet) is a chemical that is found naturally in the body. SAMe has also been studied for other liver diseases, including. It’s made in the body from methionine, an amino acid found in foods. Fibromyalgia is chronic and widespread pain in the muscles and connective tissue. Other uses not proven with research have included treating liver disease, heart disease, schizophrenia, anxiety, tendonitis, chronic back pain, migraine headaches, seizures, premenstrual syndrome, and chronic fatigue syndrome. Commercial companies produce Denamarin and Denosyl (labeled as kidney mixes containing SAM-e and Silybin) as supplements for pets. There’s a theoretical concern about the use of SAMe by people who are immunocompromised (such as those who are HIV-positive). Research shows that SAM-e levels tend to be lower in depressed individuals compared to individuals who don’t report signs of depression, so it’s believed that it does have beneficial effects when used for depression, but most of the trials that have been conducted only lasted a few weeks and included a small number of participants. It has enough research backing it up and works fairly quickly than other medications. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. Obesity 5. SAM-e is made naturally in the body, and it has been found to regulate key functions in our living cells. ), 11 Best Sugar Substitutes (the Healthiest Natural Sweeteners), Quercetin: 8 Proven Benefits of This Antioxidant (#1 Is Incredible), Chia Seeds Benefits: The Omega-3, Protein-Packed Superfood, 9 Proven Black Seed Oil Benefits that Boost Your Health, Top 15 Potassium-Rich Foods to Start Eating Today, Top 7 Foods that Boost Testosterone (Plus Testosterone-Killing Foods), What Is Allspice? SAM-e is created by the body from an essential amino acid called methionine. Small Business Research Grant Program (SBIR), About Research Training and Career Development, Training Grant Application, Review, and Award Process, Integrative Medicine Research Lecture Series, Division of Extramural Research Sponsored by NCCIH, Division of Intramural Research Conducted at NCCIH, How To Find Information About Complementary Health Approaches on PubMed, https://www.nih.gov/health-information/nih-clinical-research-trials-you. Since it does seem to be working for you, I can reassure you on one point: There is no reliable evidence that SAM-e increases risk of cancers or thyroid disease. However, whether SAMe is beneficial for liver diseases in people has not been established. The brain synthesizes SAM-e, or s-adenosylmethionine, from methionine, an essential amino acid that plays an important role in the growth of new blood vessels, and adenosine triphosphate, an energy-producing compound that acts as a source of fuel within our cells. SAM-e for dogs is a dietary supplement that mimics the SAM-e that is naturally made by the body. So is SAM-e worth the hype? My blood creatinine of 1.60 mg/dL, age 72, male, diabetic with HbA1c of 5.5%. This prompted researchers to investigate whether SAMe might be helpful in treating these conditions. You're having trouble sleeping. There is no information about using SAM-E in dialysis patients. ... Jones K, Ernst D, and et al. Dental Pulp from New Born Foals Help Orthopedic Disease in Horses. SAM-e should be taken on an empty stomach, but keep in mind that it can be stimulating, so consider taking it earlier in the day so that it doesn’t disturb your sleep. Kidney disease, or renal disease, also known as nephropathy, is damage to or disease of a kidney. Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. It can also be made in the laboratory. Researchers are still collecting evidence on the analgesic properties of S-adenosylmethionine, but there are some promising studies out there. Loss of appetite 4. Nine patients with alcoholic liver disease were given SAM-e; seven patients with non-alcoholic liver disease were given SAM-e; 8 patients with alcoholic liver disease were given a placebo; and 15 normal subjects served as a control group. SAMe is sold in the United States as a dietary supplement. If your kitchen is usually stocked with a variety of herbs and ... Bay leaf is often called for in recipes like soups and sauces ... A story has it that Mark Twain called the cherimoya “the most ... MTHFR Mutation Symptoms, Diagnoses & Natural Remedies, Detox Your Liver: Try My 6-Step Liver Cleanse, Apple Cider Vinegar Benefits and Uses (30! SAMe is involved in the formation, activation, or breakdown of other chemicals in the body, including hormones, proteins, phospholipids, and certain drugs.. Antidepressants, dextromethorphan, meperidine, pentazocine, and tramadol should be used with caution when given with SAMe. Plus, those taking SAM-e were less likely to report adverse effects when compared to patients using NSAIDs for osteoarthritis. This double-blind, randomized clinical trial suggests that gender might impact the antidepressant efficacy of SAM-e, with greater therapeutic effects found among males. In the worst-case scenario, it could necessitate a kidney transplant. If you live with a condition like osteoarthritis or depression, you may already know how it can affect other aspects of your health, contributing to issues like weight gain, difficulty sleeping, and chronic pain. To provide resources that help answer health questions, MedlinePlus (a service of the National Library of Medicine) brings together authoritative information from the National Institutes of Health as well as other Government agencies and health-related organizations. Nephritis is an inflammatory kidney disease and has several types according to the location of the inflammation. It has been found to regulate key functions in living cells. S-adenosylmethionine may worsen symptoms of mania, so it’s advised that people with bipolar disorder do not take the supplement unless it’s under the supervision of their health care provider. Decreased mental sharpness 8. Does this indicate CKD and if so, what stage and what should I do? A 2013 pilot study conducted at the University of California found that oral SAM-e was able to reduce stomach pain among children. SAMe may decrease the effects of levodopa (L-dopa), a drug used to treat Parkinson’s disease. & detox juicing guide. Side effects of SAMe are uncommon, and when they do occur they are usually minor problems such as nausea or digestive upsets. Because the ability to methylate declines with age, the risk of neurodegenerative diseases, like Alzheimer’s, increases. Studies involving children using SAM-e have been conducted and resulted in minimal toxicity, but do not start your child on SAM-e or any supplement without consulting his or her pediatrician first. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. Many doctors recommend starting with a smaller dosage of 400 milligrams a day and then increasing the dosage slowly if you are tolerating it well. Stage 1 CKD means you have mild kidney damage and an eGFR of 90 or … When they do occur, they are usually minor complains like digestive issues or nausea, but there have been cases of SAM-e triggering side effects like anxiety, insomnia and nervousness. Note that the numbers in parentheses (1, 2, etc.) Side effects are uncommon but may include mild stomach upset. Some people have symptoms of kidney failure while others do not; however whey they do occur they include shortness of breath, generalized swelling, and congestive heart failure. S-Adenosylmethionine in liver health, injury, and cancer. S-Adenosyl-L-methionine (also called S-adenosyl methionine, S-adenosylmethionine, SAMe, or SAM-e in the United States or ademetionine in Europe, and also often abbreviated as SAM and AdoMet) is a chemical that is found naturally in the body. Chest pain, if fluid builds up around the lining of the heart 12. Overall, there has been evidence that SAM-e helps improve a host of conditions, including depression, liver disease, osteoarthritis and fibromyalgia. If you’re pregnant or nursing a child, if you take medicine or other dietary supplements, if you have bipolar disorder or Parkinson’s disease, if you’re HIV-positive, or if you’re considering giving SAMe to a child, it’s especially important to consult your (or your child’s) health care provider. Prior to beginning treatment, all patients had very low hepatic glutathione levels compared to controls. (8). SAMe has also been studied for other conditions, including fibromyalgia, migraine, schizophrenia, Alzheimer’s disease, and attention-deficit hyperactivity disorder, but there isn’t enough evidence to reach conclusions about its effects in these conditions. Interventions for treating cholestasis in pregnancy. The side effects of SAM-e appear to be uncommon. Website: https://pubmed.ncbi.nlm.nih.gov/. SAMe helps produce and regulate hormones and maintain cell membranes.A synthetic version of SAMe is available as a dietary supplement in the U.S. Causes of acute and chronic kidney failure include medications, cancer, and cirrhosis. SAMe (S-adenosy-L-methionine), a dietary supplement (pronounced “sammy”), is used to treat depression, arthritis, and some liver disorders. Like most benefits associated with S-adenosylmethionine, it’s still unclear whether or not the supplement can definitely improve cognitive impairment in humans, but there are some promising animal studies on the topic. SAM-e, or s-adenosylmethionine, is a compound that comes from methionine, an essential amino acid, and adenosine triphosphate, an energy-producing compound. Changes in how much you urinate 7. Have you heard the hype about SAM-e? Heart disease 4. At least 40 studies in people have evaluated SAMe for depression, and many of them showed evidence of beneficial effects. Research has evaluated several potential uses of SAMe, and a substantial number of studies on depression and liver diseases have been completed. (7), A 2002 study published in the Journal of Family Practice found that SAM-e appears to be as effective as NSAIDs in reducing pain and improving functional limitation in patients with osteoarthritis. Swelling of feet and ankles 10. SAM-e may interact with other medications, so if you do start taking any, please discuss with your doctor or pharmacist. Several placebo-controlled studies have demonstrated the antidepressant properties of S-adenosylmethionine, but as of now, the evidence is not conclusive. Diagnosing Asthma in Horses. SAM-e is made in the body from methionine, an amino acid that’s found in foods like egg whites, wild-caught fish, oats and sesame seeds. Immunocompromised people are at risk for. 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